Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonsynthetizing multiple myeloma.

J Amir, W B Forman, A Rassiga

    Haematologia
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    This study reports a rare case of multiple myeloma without monoclonal protein synthesis. Diagnosis in such cases may rely solely on bone marrow or plasma cell tumor biopsy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Interventional Cultural and Language Assistance Program: Associations between Cultural and Linguistic Factors and Satisfaction with Cancer Care.

    Journal of community medicine & health education·2018
    Same author

    Children post liver transplantation hospitalized with fever are at a high risk for bacterial infections.

    Transplant infectious disease : an official journal of the Transplantation Society·2016
    Same author

    Hepatic involvement in congenital cytomegalovirus infection - infrequent yet significant.

    Journal of viral hepatitis·2014
    Same author

    Characteristics of non-typhi Salmonella gastroenteritis associated with bacteremia in infants and young children.

    Infection·2011
    Same author

    The efficacy and safety of valganciclovir vs. oral ganciclovir in the prevention of symptomatic CMV infection in children after solid organ transplantation.

    Pediatric transplantation·2010
    Same author

    Iloprost treatment for refractory Raynaud's phenomenon in two infants.

    Clinical and experimental rheumatology·2008
    Same journal

    The use of granulocyte colony-stimulating factor in a neutropenic renal transplant recipient.

    Haematologia·2003
    Same journal

    Heterozygous methylene tetrahydrofolate reductase mutation with mild hyperhomocysteinemia associated with deep vein thrombosis.

    Haematologia·2003
    Same journal

    Congenital methemoglobinemia due to NADH-methemoglobin reductase deficiency in three Indian families.

    Haematologia·2003
    Same journal

    Angiocentric lymphomatoid granulomatosis and severe hypogammaglobulinaemia.

    Haematologia·2003
    Same journal

    Vena cava superior syndrome due to sternal plasmacytoma in the course of systemic myeloma.

    Haematologia·2003
    Same journal

    Hepatosplenic gamma delta T-cell lymphoma with leukemic phase successfully treated with 2-chlorodeoxyadenosine.

    Haematologia·2003
    See all related articles

    Area of Science:

    • Hematology
    • Oncology
    • Immunology

    Background:

    • Multiple myeloma is a malignancy of plasma cells, typically characterized by the overproduction of a monoclonal immunoglobulin.
    • The presence of monoclonal protein in serum or urine is a hallmark diagnostic criterion for multiple myeloma.

    Observation:

    • This case presents a patient with clinical and pathological features of multiple myeloma, including hypogammaglobulinemia, bone marrow infiltration, osteolytic bone lesions, and plasma cell tumors.
    • Crucially, extensive investigations revealed a complete absence of detectable monoclonal protein synthesis.

    Findings:

    • Bone marrow culture using tritiated leucine confirmed the absence of protein synthesis by the malignant plasma cells.
    • No evidence of immunoglobulin production was detected, challenging conventional diagnostic approaches for multiple myeloma.

    Related Experiment Videos

    Implications:

    • This case highlights the existence of 'non-secretory' multiple myeloma, necessitating alternative diagnostic strategies.
    • Bone marrow biopsy and plasma cell tumor biopsy may be the definitive diagnostic methods when monoclonal protein is absent.