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Biological markers in mental disorders: post-mortem studies.

M Rossor

    Journal of Psychiatric Research
    |January 1, 1984
    PubMed
    Summary

    Post-mortem brain tissue analysis reveals stable neurotransmitters, enzymes, and receptors for studying mental disorders. Careful exclusion of non-specific factors is crucial for accurate disease-related neurochemical findings.

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    Area of Science:

    • Neuroscience
    • Psychiatry
    • Neuropathology

    Background:

    • Neurotransmitters, enzymes, and receptors are often stable post-mortem, allowing measurement in autopsy samples.
    • Comparing brain tissue from control and disease cases can reveal neurochemical alterations in mental disorders.

    Purpose of the Study:

    • To discuss the challenges and considerations in interpreting post-mortem neurochemical findings in mental disorders.
    • To highlight the importance of excluding non-specific factors when assessing disease-related changes in neurotransmitter systems.

    Main Methods:

    • Review and discussion of post-mortem studies.
    • Focus on neurochemical analysis of brain tissue.
    • Consideration of confounding variables: age, agonal state, drug therapy, and post-mortem stability.

    Main Results:

    • Post-mortem neurochemical analysis is feasible for studying neurotransmitter systems.
    • Non-specific factors can significantly influence measured neurochemical profiles.
    • Distinguishing disease-specific changes from alterations in neuronal turnover can be challenging.

    Conclusions:

    • Post-mortem brain analysis is valuable for understanding mental disorders, but requires rigorous control for confounding variables.
    • Careful methodology is essential to attribute observed neurochemical changes to specific disease processes, such as schizophrenia and Alzheimer's disease.

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