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Thyrotropin-releasing hormone levels decrease in hypothalamus of aging rats.

A E Pekary, H E Carlson, T Yamada

    Neurobiology of Aging
    |January 1, 1984
    PubMed
    Summary
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    Aging significantly reduces thyrotropin-releasing hormone (TRH) and thyroxine (T4) levels in male rats. These changes in TRH may contribute to a diminished thyroid-stimulating hormone (TSH) response to cold stress in older animals.

    Area of Science:

    • Neuroendocrinology
    • Aging Research
    • Reproductive Biology

    Background:

    • Thyrotropin-releasing hormone (TRH) levels change significantly during early development in rats.
    • Advanced aging may also impact TRH levels and related hormonal axes.

    Purpose of the Study:

    • To investigate the effects of aging on hypothalamic and reproductive TRH-IR levels.
    • To assess changes in other key hormones including somatostatin (SRIF), beta-endorphin (EP), prolactin (Prl), growth hormone (GH), thyrotropin (TSH), and thyroxine (T4) in aging male rats.

    Main Methods:

    • Measurement of hypothalamic and prostatic TRH-IR, hypothalamic SRIF and EP, and serum Prl, GH, TSH, and T4.
    • Comparison between young, sexually mature rats and aged (24-28 months old) male Long-Evans and Sprague-Dawley rats.

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  • High-pressure liquid chromatography (HPLC) was used to characterize TRH and TRH-like peptides.

    • Main Results:

    • Aged rats exhibited significantly reduced hypothalamic and prostatic TRH-IR levels.
    • Serum thyroxine (T4) levels were also lower in aged rats compared to young controls.
    • Hypothalamic SRIF and EP levels remained unchanged with aging, and the TRH to TRH-like peptide ratio in the prostate was consistent.

    Conclusions:

    • Aging leads to decreased hypothalamic TRH levels and potentially reduced TRH secretory capacity in male rats.
    • These age-related hormonal changes, particularly in TRH, may underlie the blunted TSH response to cold stress observed in older rats.