Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Benzodiazepines and memory.

T Roth, T Roehrs, R Wittig

    British Journal of Clinical Pharmacology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Benzodiazepines cause anterograde amnesia, impacting short and long-term memory. This memory disruption, particularly in long-term recall, stems from sleep onset interference with memory consolidation, not drug retrieval effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    How representative are insomnia clinical trials?

    Sleep medicine·2018
    Same author

    Deletion of Menin in craniofacial osteogenic cells in mice elicits development of mandibular ossifying fibroma.

    Oncogene·2017
    Same author

    The status of sleep abnormalities as a diagnostic test for major depressive disorder.

    Journal of affective disorders·2014
    Same author

    Reactions of cloned poplars to air pollution : Ozone-induced increase of stress ethylene and possible antisenescence strategies.

    Environmental science and pollution research international·2013
    Same author

    Reciprocal effects of platinum and lead on the water household of poplar cuttings.

    Environmental science and pollution research international·2013
    Same author

    Light exposure and cell viability in fluorescence microscopy.

    Journal of microscopy·2011
    Same journal

    N-acetylcysteine for non-paracetamol-induced acute liver failure in children: A systematic review and meta-analysis.

    British journal of clinical pharmacology·2026
    Same journal

    Anti-seizure medications and DRESS in paediatric patients: A FAERS disproportionality and time-to-onset analysis.

    British journal of clinical pharmacology·2026
    Same journal

    Modelling immune gene expression profiles as pharmacodynamic endpoints of antileishmanial treatment.

    British journal of clinical pharmacology·2026
    Same journal

    The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone.

    British journal of clinical pharmacology·2026
    Same journal

    Relationship between continuous infusion meropenem PK/PD target attainment and C-reactive protein dynamics in onco-haematologic patients with febrile neutropenia.

    British journal of clinical pharmacology·2026
    Same journal

    UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).

    British journal of clinical pharmacology·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Cognitive Psychology

    Background:

    • Benzodiazepines are commonly prescribed medications with known central nervous system effects.
    • Anterograde amnesia is a recognized side effect, impairing the formation of new memories.
    • Understanding the precise mechanisms of benzodiazepine-induced memory impairment is crucial for patient safety.

    Purpose of the Study:

    • To investigate the relationship between benzodiazepine dosage, half-life, and the extent of amnesia.
    • To identify specific memory systems affected by benzodiazepines.
    • To elucidate the underlying mechanisms of long-term memory deficits induced by these drugs.

    Main Methods:

    • Systematic analysis of dose-dependent and half-life related amnesic effects.

    Related Experiment Videos

  • Assessment of memory deficits across episodic, semantic, and iconic memory domains.
  • Distinguishing between consolidation and retrieval processes in memory disruption.

    • Main Results:

    • Benzodiazepines induce dose-dependent anterograde amnesia affecting multiple memory types.
    • Long-term memory deficits are linked to impaired memory consolidation.
    • Rapid sleep onset, induced by benzodiazepines, appears to be the primary cause of retrograde amnesia.

    Conclusions:

    • Benzodiazepine-induced long-term amnesia is primarily a consequence of disrupted memory consolidation.
    • The observed retrograde amnesia is attributed to the effects of rapid sleep onset, not direct drug action on memory retrieval.
    • Further research should focus on mitigating sleep-related memory disruption in patients using benzodiazepines.