Side-effects of salazopyrin on male fertility

The author critically studied the twelve papers and letters to the editor published since 1979 regarding toxic effects of Salazopyrin on male fertility. A direct toxic side-effect of Salazopyrin on the maturation of sperm cells is apparent, but associated influencing factors are the basic illness itself and associated therapy forms, such as steroids, that also influence spermatogenesis. The mechanism of action of Salazopyrin is still a matter of dispute. Possible (and possibly combined) interfering factors are: an anti-folate action with influence on the rapid turnover of dividing spermatogenic cells, an anti-prostaglandin effect on motility and toxic effects of the sulphapyridine substance of Salazopyrin.