Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Molecular regulators of brain function: a new view.

F O Schmitt

    Neuroscience
    |December 1, 1984
    PubMed
    Summary

    Neurons are regulated by more than just neurotransmitters; a parallel parasynaptic system uses informational substances for versatile communication. This system offers plasticity beyond traditional synaptic connections.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    An investigation of cross striations and myosin filaments in muscle.

    The Biological bulletin·2010
    Same author

    The growing importance of physics in the premedical and medical curriculums.

    Archives of physical medicine and rehabilitation·2010
    Same author

    Walle J. H. Nauta (8 June 1916-24 March 1994).

    Proceedings of the American Philosophical Society·1995
    Same author

    Adventures in molecular biology.

    Annual review of biophysics and biophysical chemistry·1985
    Same author

    Energy transduction in neuroscience.

    Bio Systems·1977
    Same author

    Aharon Katchalsky the person. Summary remarks and personal recollections.

    Advances in biological and medical physics·1977

    Area of Science:

    • Neuroscience
    • Molecular Biology
    • Cellular Signaling

    Background:

    • Traditional neuroscience focuses on neurotransmitters and synaptic junctions for neuronal regulation.
    • Emerging research suggests a broader range of informational substances influence neuronal function.
    • DNA technology is continually discovering novel signaling molecules.

    Purpose of the Study:

    • To propose a hypothesis integrating known and novel informational substances in neuronal regulation.
    • To introduce the concept of a parasynaptic system operating alongside conventional synaptic circuitry.
    • To highlight the plasticity and versatility of this parasynaptic communication.

    Main Methods:

    • Conceptual framework development based on existing literature.
    • Categorization of known informational substances (transmitters, peptides, hormones, factors, proteins).
    • Integration of findings from DNA technology regarding new substance discovery.

    Main Results:

    • Neurons are regulated by neurotransmitters and a diverse array of other informational substances.
    • A parasynaptic system, distinct from synaptic junctions, utilizes diffusion for signaling.
    • The parasynaptic system exhibits high selectivity, versatility, and plasticity.

    Conclusions:

    • The nervous system employs both synaptic and parasynaptic communication pathways.
    • Parasynaptic signaling contributes significantly to neuronal plasticity and functional regulation.
    • Understanding these diverse signaling mechanisms is crucial for advancing neuroscience.

    Related Experiment Videos