Effects of nitroheterocyclic sensitizers on erythrocyte membranes ATP-ase activity

The effect of two nitroimidazoles, 1(2'-hydroxy-3'-chloropropyl)-2-methyl-4-nitroimidazol and 1(2'-hydroxy-3'-chloropropyl)-2-methyl-5-nitroimidazol and irradiation on erythrocyte membrane ATP-ase activity was studied. The action of nitroimidazole derivatives on the erythrocyte membrane ATP-ase activity differed depending on the nitro group position. 5-Nitroimidazole derivative in the concentration of 300 micrograms/mg protein inhibited significantly the non-irradiated erythrocyte membrane (Na+, K+) ATP-ase activity, while 4-NO2 in the concentration of 3 micrograms/mg protein influenced this activity, but only after an exposure at dose of 60 Krad. In the concentration of 300 micrograms/mg membrane protein it activated this ATP-ase.