Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatic dysfunction after open-heart surgery.

R Olsson, S Hermodsson, D Roberts

    Scandinavian Journal of Thoracic and Cardiovascular Surgery
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Re: Correlation between subjective and objective evaluation of the nasal airway. A systematic review of the highest level of evidence.

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2010
    Same author

    Permacol in augmentation rhinoplasty.

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2010
    Same author

    Balloon sinuplasty: our first year.

    The Journal of laryngology and otology·2010
    Same author

    A qualitative study exploring perceptions and experiences of patients and clinicians of palliative medicine outpatient clinics in different settings.

    Palliative medicine·2010
    Same author

    Outsourcing of ultrasound services in obstetrics and gynecology.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2010
    Same author

    Structure-activity relationships in toxicology and ecotoxicology: An assessment.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same journal

    Transdiaphragmatic cyst-jejunostomy with Roux-en-Y loop for an exclusively mediastinal pancreatic pseudocyst.

    Scandinavian journal of thoracic and cardiovascular surgery·1996
    Same journal

    Long survival in small-cell (neuroendocrine) carcinoma of the mediastinum.

    Scandinavian journal of thoracic and cardiovascular surgery·1996
    Same journal

    Intrathoracic malignant peripheral nerve-sheath tumour associated with lipoma.

    Scandinavian journal of thoracic and cardiovascular surgery·1996
    Same journal

    Profuse mediastinal haemorrhage due to mediastinitis after sternotomy. Report of three cases and review of the literature.

    Scandinavian journal of thoracic and cardiovascular surgery·1996
    Same journal

    Cystic medical necrosis of the internal thoracic artery.

    Scandinavian journal of thoracic and cardiovascular surgery·1996
    Same journal

    DNA flow cytometric analysis of chest-wall chondroma and chondrosarcoma.

    Scandinavian journal of thoracic and cardiovascular surgery·1996
    See all related articles

    Open-heart surgery can cause early liver enzyme elevation, potentially from myocardial and liver damage. Some patients develop non-A, non-B hepatitis post-transfusion, leading to prolonged liver dysfunction.

    Area of Science:

    • Cardiology
    • Hepatology
    • Transfusion Medicine

    Background:

    • Open-heart surgery often involves hypothermia, hemodilution, and cold cardioplegia.
    • Postoperative monitoring of liver function is crucial following cardiac procedures.

    Purpose of the Study:

    • To investigate the pattern and incidence of liver dysfunction after open-heart surgery.
    • To assess the potential causes of early and late liver enzyme abnormalities.

    Main Methods:

    • Prospective observation of 93 patients up to nine months post-open-heart surgery.
    • Frequent monitoring of liver enzymes (AST, ALT, ALP, GGT), bilirubin, and bile acids in the early postoperative period.
    • Monthly monitoring of liver enzymes and bilirubin after the initial two weeks.
    • Measurement of plasma hemoglobin post-operation.

    Related Experiment Videos

    Main Results:

    • On postoperative day one, elevated AST and AST/ALT ratio > 1 were observed in most patients, suggesting myocardial and liver enzyme leakage.
    • Approximately 25% of patients exhibited hyperbilirubinemia early post-surgery.
    • After two weeks, a different pattern of liver dysfunction emerged, with 50% showing elevated ALT and abnormal ALP and GGT in 28% and 45% of cases, respectively.
    • Eight patients were diagnosed with non-A, non-B post-transfusion hepatitis, with six experiencing prolonged aminotransferase elevation for over six months.

    Conclusions:

    • Early postoperative liver enzyme elevations after open-heart surgery may indicate both myocardial and hepatic injury.
    • A significant proportion of patients may develop non-A, non-B post-transfusion hepatitis, contributing to sustained liver dysfunction.
    • Long-term monitoring is recommended for patients undergoing open-heart surgery, especially those receiving transfusions.