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Beta-adrenergic blockade alone does not decrease renal perfusion in black hypertensives.

D C Brater, S Anderson, N M Kaplan

    Journal of Hypertension
    |February 1, 1984
    PubMed
    Summary
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    Beta-adrenergic blockade does not harm renal function in hypertensive patients. This study found pure beta-blockade, without significant blood pressure reduction, did not decrease renal perfusion.

    Area of Science:

    • Nephrology
    • Cardiology
    • Pharmacology

    Background:

    • Essential hypertension is a common condition.
    • Beta-adrenergic blockers are widely used antihypertensives.
    • Concerns exist regarding their effects on renal hemodynamics.

    Purpose of the Study:

    • To assess the impact of beta-adrenergic blockade on renal hemodynamics.
    • To differentiate effects of pure beta-blockade from those of reduced blood pressure.

    Main Methods:

    • 18 black patients with essential hypertension were studied.
    • Acute and chronic (2 months) administration of atenolol, nadolol, or propranolol.
    • Renal hemodynamics were assessed in patients with minimal antihypertensive response.

    Related Experiment Videos

    Main Results:

    • Neither acute nor chronic beta-blockade decreased renal perfusion.
    • Antihypertensive response was minimal in this patient cohort.
    • Pure beta-blockade did not negatively affect renal hemodynamics.

    Conclusions:

    • Beta-blockade itself does not adversely affect renal function.
    • Previous findings of renal impairment are likely due to blood pressure reduction.
    • Unopposed alpha-sympathetic vasoconstriction may play a role when blood pressure is lowered.