Atypical thyroid dermopathy: clinical and immunological features of two cases

Two cases of pretibial and atypical dermopathy in Graves' disease, showing many similarities in clinical pictures and natural histories, are reported. In both patients we observed abnormalities of some immunological parameters, namely reduction of Fc-positive T lymphocytes and positive TBI indexes. These abnormalities were concomitant to the appearance of dermopathy and apparently unrelated to other clinical manifestations of Graves' disease.