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Effects of beta-adrenoceptor blockade on prostacyclin mediated renin release in sheep
Clinical and Experimental Pharmacology & Physiology
|November 1, 1984
Abstract:
The effect of prostacyclin (PGI2) infusion on plasma renin concentration (PRC) was examined before and after propranolol treatment in sheep. Increasing doses of prostacyclin (0.05, 0.1 or 0.3 micrograms/kg per min) produced dose dependent increases in PRC. There was a significantly lower PRC response after propranolol at 0.3 micrograms/kg per min only.