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Related Experiment Videos

Will progesterone save the IUD?

R M Soderstrom1

  • 1Department of Obstetrics and Gynecology, Mason Clinic, Seattle, Washington.

The Journal of Reproductive Medicine
|May 1, 1983
PubMed
Summary
This summary is machine-generated.

Nonhormonal intrauterine devices (IUDs) were linked to a 49% rate of subclinical salpingitis, increasing pelvic inflammatory disease (PID) risk. Progesterone-releasing IUDs significantly lowered this risk, suggesting a protective effect.

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Area of Science:

  • Gynecology
  • Infectious Disease Epidemiology

Background:

  • Pelvic inflammatory disease (PID) is a significant concern for intrauterine device (IUD) users.
  • Understanding the specific risks associated with different types of IUDs is crucial for patient counseling and management.

Purpose of the Study:

  • To investigate the association between nonhormonal IUDs and progesterone-releasing IUDs (Progestasert) with subclinical salpingitis and PID risk.
  • To compare PID risk in IUD users versus non-users.

Main Methods:

  • Histological examination of fallopian tube specimens from four groups: nonhormonal-IUD users, Progestasert users, non-IUD users, and past IUD users.
  • Bacteriological cultures were performed on select specimens.

Main Results:

Related Experiment Videos

  • Histologically detectable salpingitis was found in 49% of nonhormonal-IUD users, with sterile cultures.
  • No Progestasert users exhibited salpingitis, a statistically significant difference (p < 10(-6)).
  • PID risk appears higher in IUD users compared to non-users, potentially due to inflammation predisposing to infection.

    • Conclusions:

    • Progesterone-releasing IUDs (Progestasert) are associated with a significantly lower risk of developing PID compared to nonhormonal IUDs.
    • Subclinical inflammation in nonhormonal IUD users may increase susceptibility to PID.