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Antigen-specific factors produced by carrier-primed New Zealand Black mice
We studied antigen-specific suppression in NZB and B/W mice to investigate immunoregulatory circuits associated with autoimmune disease. Young NZB and B/W mice produced ample suppressor factor, and acceptor cells were present even in older mice. A low m.w. antigen-specific enhancing factor capable of augmenting the secondary in vitro IgG antibody response to DNP was found. These results indicate the complexity of immunoregulation in these autoimmune-susceptible mice.
We studied antigen-specific suppression in NZB and B/W mice to investigate immunoregulatory circuits associated with autoimmune disease. Young NZB and B/W mice produced ample suppressor factor, and acceptor cells were present even in older mice. A low m.w. antigen-specific enhancing factor capable of augmenting the secondary in vitro IgG antibody response to DNP was found. These results indicate the complexity of immunoregulation in these autoimmune-susceptible mice.