Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The axonal pathology in chronic IDPN intoxication.

A W Clark, J W Griffin, D L Price

    Journal of Neuropathology and Experimental Neurology
    |January 1, 1980
    PubMed
    Summary

    Neurofilament accumulation causes axonal swelling and atrophy in neurological disorders. Impaired slow axonal transport is identified as a key mechanism in experimental models, suggesting its role in human neurodegenerative diseases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Intermediate-range order in permanently densified GeO2 glass.

    Physical review letters·2003
    Same author

    Microscopic dynamics of liquid aluminum oxide.

    Science (New York, N.Y.)·2003
    Same author

    Effects of anti-odor automobile air-conditioning system products on adherence of Serratia marcescens to aluminum.

    Journal of industrial microbiology & biotechnology·2002
    Same author

    Genetically engineered models relevant to neurodegenerative disorders: their value for understanding disease mechanisms and designing/testing experimental therapeutics.

    Journal of molecular neuroscience : MN·2002
    Same author

    beta-Amyloid peptide vaccination results in marked changes in serum and brain Abeta levels in APPswe/PS1DeltaE9 mice, as detected by SELDI-TOF-based ProteinChip technology.

    DNA and cell biology·2002
    Same author

    Choroid plexus carcinoma presenting as an intraparenchymal mass.

    Journal of neurosurgery·2002

    Area of Science:

    • Neuroscience
    • Neuropathology
    • Toxicology

    Background:

    • Neurofilamentous axonal swellings are observed in various nervous system disorders.
    • Experimental models are crucial for understanding the underlying mechanisms of neurodegeneration.

    Purpose of the Study:

    • To investigate the role of slow axonal transport in neurofilament accumulation and axonal morphology changes.
    • To elucidate the pathological mechanisms in experimental beta, beta'-iminodiproprionitrile (IDPN) intoxication.

    Main Methods:

    • Induction of experimental intoxication using beta, beta'-iminodiproprionitrile (IDPN).
    • Analysis of neurofilament accumulation and axonal morphology.
    • Assessment of slow axonal transport function.

    Related Experiment Videos

    Main Results:

    • IDPN intoxication leads to neurofilament accumulation in the proximal axon.
    • Proximal axonal swelling and distal axonal atrophy were observed.
    • The neurofilament accumulation resulted from a defect in slow axonal transport.

    Conclusions:

    • Impaired slow axonal transport is a primary cause of neurofilamentous axonal swellings and atrophy.
    • Axonal atrophy is a secondary consequence of disrupted axonal transport.
    • This mechanism may be relevant to other neurodegenerative and toxic neuropathies.