Related Experiment Video

Updated: Oct 1, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

The ultrasonic and biochemical diagnosis of pancreatitis in children

K L Cox, M E Ament, W F Sample

    The Journal of Pediatrics
    |March 1, 1980
    PubMed

    Insights

    Pediatric abdominal pain evaluation using pancreatic ultrasonography showed reduced pancreatic echodensity in some children. Serum amylase and clearance ratios poorly correlated with pancreatitis findings.

    Area of Science:

    • Pediatric Gastroenterology
    • Diagnostic Imaging
    • Biochemistry

    Background:

    • Abdominal pain is a common pediatric complaint.
    • Diagnosing pancreatitis in children can be challenging.
    • Current diagnostic markers may have limitations.

    Purpose of the Study:

    • To evaluate the utility of pancreatic ultrasonography in children with abdominal pain.
    • To compare ultrasonographic findings with serum amylase and amylase creatinine clearance ratio.
    • To assess the correlation between imaging and biochemical markers for pancreatitis.

    Main Methods:

    • Pancreatic ultrasonography was performed on 17 normal children and 35 children with abdominal pain.
    • Serum amylase levels and amylase creatinine clearance ratio were determined.
    • Echogenicity of the pancreas was compared to the liver in normal subjects.

    Main Results:

    • Normal children exhibited pancreatic echodensity equal to or greater than the liver.
    • Nineteen children with abdominal pain showed reduced pancreatic echodensity.
    • Two of these 19 patients developed pseudocysts.
    • Serum amylase and amylase creatinine clearance ratio showed poor correlation with ultrasonic and clinical pancreatitis evidence.

    Conclusions:

    • Pancreatic ultrasonography may reveal abnormalities in children with abdominal pain.
    • Reduced pancreatic echodensity can be an indicator of pancreatitis in pediatric patients.
    • Serum amylase and amylase creatinine clearance ratio have limited value in diagnosing pediatric pancreatitis.

    More Related Videos

    Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection07:38

    Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

    Published on: May 10, 2024

    An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation06:28

    An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

    Published on: October 31, 2025

    Related Concept Videos

    Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

    Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

    Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
    Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
    Acute Pancreatitis I: Introduction01:27

    Acute Pancreatitis I: Introduction

    Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
    Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
    The causes of acute pancreatitis include:
    Chronic Pancreatitis I: Introduction01:24

    Chronic Pancreatitis I: Introduction

    The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
    Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
    Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
    Chronic Pancreatitis II: Collaborative Care01:29

    Chronic Pancreatitis II: Collaborative Care

    The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
    Assessment:
    Acute Pancreatitis I: Introduction01:25

    Acute Pancreatitis I: Introduction

    Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
    Chronic Pancreatitis II: Pathophysiology01:21

    Chronic Pancreatitis II: Pathophysiology

    Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...