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Retrovirus-like particles released by human prostatic cells.

S K Arya, L Job, R Chawda

    Oncology
    |January 1, 1980
    PubMed
    Summary
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    Human prostatic cells cultured from benign prostatic hyperplasia tissue release retrovirus-like particles. These particles contain RNA and RNA-directed DNA polymerase, suggesting potential retrovirus production in the prostate.

    Area of Science:

    • Cell Biology
    • Virology
    • Oncology

    Background:

    • Human prostatic tissue diagnosed with benign prostatic hyperplasia was used for cell culture.
    • The cultured cells exhibited a normal male human karyotype with a chromosome model number ranging from 43 to 46.

    Purpose of the Study:

    • To investigate the potential release of retrovirus-like entities from cultured human prostatic cells.
    • To characterize the properties of extracellular particles produced by these cells.

    Main Methods:

    • Cell culture of human prostatic tissue with benign prostatic hyperplasia.
    • Isolation and characterization of extracellular particulate material from culture medium using sucrose density gradient and sedimentation rate analysis.
    • Analysis of nucleic acid content (RNA) and enzymatic activity (RNA-directed DNA polymerase).

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    Main Results:

    • Retrovirus-like particles were released into the culture medium.
    • These particles banded at a density of 1.12–1.18 g/ml and had sedimentation rates similar to known retroviruses.
    • Particles contained RNA and RNA-directed DNA polymerase, synthesized DNA using poly (Cm) template, and showed endogenous DNA polymerase activity.
    • Synthesized DNA was associated with RNA, including high molecular weight RNA, though a 60–70S RNA species was not detected.

    Conclusions:

    • The findings suggest that human prostatic cells may produce retroviruses.
    • Further investigation is needed to confirm the presence and nature of these retroviral agents.