Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Disopyramide-induced ventricular tachycardia.

K S Lo, K B Gantz, P L Stetson

    Archives of Internal Medicine
    |March 1, 1980
    PubMed
    Summary

    Disopyramide phosphate treatment for ventricular arrhythmias in heart failure patients can lead to dangerous heart rhythm changes. Careful monitoring is crucial, especially in patients with impaired kidney or liver function.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Closing the Digitalis Divide: Back to the Basics of Randomized Controlled Trials.

    Cardiovascular drugs and therapy·2021
    Same author

    Depressive symptoms and hazardous/harmful alcohol use are prevalent and correlate with stigma among TB-HIV patients in Lesotho.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2017
    Same author

    Pulmonary tuberculosis diagnostic practices among people living with the human immunodeficiency virus in Lesotho.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2017
    Same author

    Impact of Hyperkalemia and Worsening Renal Function on the Use of Renin Angiotensin Aldosterone System Inhibitors in Chronic Heart Failure With Reduced Ejection Fraction.

    Clinical pharmacology and therapeutics·2017
    Same author

    Combined baseline and one-month changes in big endothelin-1 and brain natriuretic peptide plasma concentrations predict clinical outcomes in patients with left ventricular dysfunction after acute myocardial infarction: Insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) study.

    International journal of cardiology·2017
    Same author

    Mineralocorticoid receptor blockade-a novel approach to fight hyperkalaemia in chronic kidney disease.

    Clinical kidney journal·2015

    Area of Science:

    • Cardiology
    • Clinical Pharmacology

    Background:

    • Ischemic cardiomyopathy and congestive heart failure present complex management challenges.
    • Ventricular arrhythmias require effective antiarrhythmic therapies.

    Observation:

    • A patient with ischemic cardiomyopathy and congestive heart failure experienced ventricular tachycardia during disopyramide phosphate treatment.
    • This event correlated with elevated plasma disopyramide levels.
    • Electrocardiographic changes included QRS and QT interval prolongation.

    Findings:

    • Disopyramide administration was associated with impaired ventricular conduction.
    • Prolonged ventricular recovery times were observed.
    • Elevated drug levels indicated a potential for toxicity.

    Implications:

    • Disopyramide use necessitates caution in patients with congestive heart failure.
    • Renal and hepatic dysfunction significantly increase the risk of disopyramide-related adverse events.
    • Close patient monitoring and dose adjustment are critical for safe disopyramide therapy.

    Related Experiment Videos