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Dog dander allergens. Specificity studies based on the radioallergosorbent technique
International Archives of Allergy and Applied Immunology
|January 1, 1980
Summary
Many dog dander-sensitive patients have cat allergen-specific IgE antibodies. Some dog dander allergens show cross-reactivity with cat allergens, suggesting shared allergenic components.
Area of Science:
- Immunology
- Allergology
- Biochemistry
Background:
- Patients sensitive to dog dander often exhibit allergic reactions.
- Cross-reactivity between allergens from different animal species is a known phenomenon.
Purpose of the Study:
- To investigate the presence and nature of cross-reactivity between dog dander and cat allergens in sensitive patients.
- To identify and characterize allergenic components in dog dander.
Main Methods:
- Detection of serum IgE antibodies against cat and dog allergens using immunoassays.
- Inhibition assays to assess IgE binding to dog dander allergens using cat allergens.
- Chromatographic separation of dog dander allergens.
- Analysis of allergenic components in dander from various dog breeds.
Main Results:
- Elevated cat allergen-specific IgE antibodies were found in a significant portion of dog dander-sensitive patients.
- Dual IgE reactivity was partly explained by cross-reacting serum proteins.
- Cat epithelium allergens inhibited the binding of dog dander-specific IgE antibodies.
- Two distinct allergenic components were isolated from dog dander; one showed cross-reactivity with a major cat allergen, while the other was dog-specific.
- Both components were present in multiple dog breeds.
Conclusions:
- Dog dander contains allergens that cross-react with cat allergens, contributing to dual sensitization.
- A dog-specific allergen component was also identified in dog dander.
- Dog dander is a valuable source for studying dog epithelium allergens, considering potential cross-reactivity with other animal allergens.