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Elevated beta-thromboglobulin in patients with chronic renal failure: effect of hemodialysis
Elevated plasma concentrations of beta-thromboglobulin were observed in 25 consecutive patients with chronic renal failure. Further increases in this platelet protein were observed during hemodialysis but not during peritoneal dialysis. The hemodialysis-induced increases were not prevented by either aspirin or dipyridamole, a fact which suggested that release of this protein was not dependent on platelet functional activity. Measurement of beta-thromboglobulin provides a sensitive indicator of platelet disruption during hemodialysis.
Elevated plasma concentrations of beta-thromboglobulin were observed in 25 consecutive patients with chronic renal failure. Further increases in this platelet protein were observed during hemodialysis but not during peritoneal dialysis. The hemodialysis-induced increases were not prevented by either aspirin or dipyridamole, a fact which suggested that release of this protein was not dependent on platelet functional activity. Measurement of beta-thromboglobulin provides a sensitive indicator of platelet disruption during hemodialysis.