Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A decrease in irreversibly sickled erythrocytes in sicle cell anemia patients given vitamin E.

C L Natta, L J Machlin, M Brin

    The American Journal of Clinical Nutrition
    |May 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Phenylalanine loading as a diagnostic test for DRD: interpreting the utility of the test.

    Molecular genetics and metabolism·2004
    Same author

    Mutational spectrum of the CHAC gene in patients with chorea-acanthocytosis.

    European journal of human genetics : EJHG·2002
    Same author

    Criteria for the diagnosis of essential tremor.

    Neurology·2000
    Same author

    Pharmacologic treatment of essential tremor.

    Neurology·2000
    Same author

    Consensus statement of the Movement Disorder Society on Tremor. Ad Hoc Scientific Committee.

    Movement disorders : official journal of the Movement Disorder Society·1998
    Same author

    Chorea-acanthocytosis: genetic linkage to chromosome 9q21.

    American journal of human genetics·1997
    Same journal

    Nourishing Collaboration: Interdisciplinary Nutrition Education for Health Care Professionals.

    The American journal of clinical nutrition·2026
    Same journal

    Associations of red blood cell fatty acids with personality traits: 10-year follow-up in the Kibbutzim Family Study.

    The American journal of clinical nutrition·2026
    Same journal

    Corrigendum to: Vitamin D status and breast cancer in Saudi Arabian women: case-control study [Am J Clin Nutr 98 (2013) 105-110].

    The American journal of clinical nutrition·2026
    Same journal

    High postprandial endotoxemia is associated with recurrence of cardiovascular events in patients with coronary heart disease: from the CORDIOPREV randomized clinical trial.

    The American journal of clinical nutrition·2026
    Same journal

    Reply to Wu et al.: "Nitrate and nitrite food composition database: an update and extensive deep dive".

    The American journal of clinical nutrition·2026
    Same journal

    Reframing Basic Experimental Studies in Humans-Implications for Nutrition Science.

    The American journal of clinical nutrition·2026
    See all related articles

    Vitamin E supplementation significantly reduced irreversibly sickled red blood cells in sickle cell anemia patients. This finding suggests vitamin E may be a beneficial therapeutic agent for managing sickle cell disease complications.

    Area of Science:

    • Hematology
    • Nutritional Science
    • Biochemistry

    Background:

    • Sickle cell anemia is a genetic blood disorder characterized by abnormal hemoglobin.
    • Irreversibly sickled red blood cells contribute to vaso-occlusion and organ damage in sickle cell disease.

    Purpose of the Study:

    • To investigate the effect of vitamin E supplementation on red blood cell morphology in patients with sickle cell anemia.
    • To assess changes in plasma tocopherol levels and the percentage of irreversibly sickled cells.

    Main Methods:

    • Patients with sickle cell anemia received 450 IU of vitamin E (alpha-tocopherol) daily.
    • Treatment duration ranged from 6 to 35 weeks.
    • Plasma tocopherol levels and the percentage of irreversibly sickled red blood cells were measured before and after supplementation.

    Related Experiment Videos

    Main Results:

    • Plasma tocopherol levels increased significantly after vitamin E administration.
    • The percentage of circulating irreversibly sickled red blood cells decreased from 25% to 11%.
    • Reduced levels of irreversibly sickled cells were maintained throughout the vitamin E treatment period.

    Conclusions:

    • Vitamin E supplementation effectively reduces irreversibly sickled red blood cells in sickle cell anemia.
    • This suggests a potential therapeutic role for vitamin E in mitigating vaso-occlusive events.
    • Further research is warranted to explore the clinical implications and long-term benefits.