Long-term effects of conventional immunotherapy in southern California

Long-term effects of conventional immunotherapy on a variety of immunological parameters were evaluated in 31 patients with grass hay fever who attended our allergy clinic for up to three years. The mean proliferative lymphocyte response decreased significantly after the first year and the mean antigen-specific Ig antibody level increased significantly after the second year. Neither the mean antigen-specific IgE nor the mean total serum IgE level changed significantly at any point in time during the three years of immunotherapy.