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Platelet activation following cerebral angiography
Acta Neurologica Scandinavica
|April 1, 1980
Summary
Cerebral angiography activated platelets, indicated by increased beta thromboglobulin levels in most patients. Prophylactic anti-thrombotic therapy may be beneficial due to procedure-related risks.
Area of Science:
- Neurology
- Hematology
- Medical Imaging
Background:
- Cerebral angiography is a medical imaging procedure used to visualize blood vessels in the brain.
- Platelet activation is a key process in thrombosis and hemostasis.
Purpose of the Study:
- To investigate the effect of cerebral angiography on platelet activation.
- To assess the potential need for prophylactic anti-thrombotic therapy after the procedure.
Main Methods:
- Blood samples were collected from patients undergoing cerebral angiography.
- Levels of beta thromboglobulin, a marker of platelet activation, were measured.
- Statistical analysis was performed to determine the significance of changes in beta thromboglobulin levels.
Main Results:
- Beta thromboglobulin levels increased significantly (P < 0.05) in five out of seven patients following cerebral angiography.
- This suggests generalized platelet activation occurred due to the procedure.
Conclusions:
- Cerebral angiography appears to induce systemic platelet activation.
- Given the observed platelet activation and the known morbidity of the procedure, a trial of prophylactic anti-thrombotic therapy is warranted.