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Related Experiment Videos

The pathogenesis of benign prostatic hyperplasia.

J D Wilson

    The American Journal of Medicine
    |May 1, 1980
    PubMed
    Summary

    Prostatic hyperplasia in aging men and dogs is mediated by dihydrotestosterone accumulation, influenced by estrogen and androgen receptors. New therapies may avoid chemical castration.

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    Area of Science:

    • Veterinary medicine
    • Urology
    • Endocrinology

    Background:

    • Prostatic hyperplasia is common in aging men and dogs.
    • Development requires intact testes and is age-dependent.

    Purpose of the Study:

    • To propose a working hypothesis for the pathogenesis of prostatic hyperplasia.
    • To explore potential therapeutic strategies not involving chemical castration.

    Main Methods:

    • Analysis of plasma hormone levels in relation to age.
    • Measurement of androgen and androgen receptor concentrations in the prostate.
    • Hormonal administration studies in castrated dogs.

    Main Results:

    • Dihydrotestosterone accumulation within the prostate mediates hyperplasia in both species.
    • Decreased dihydrotestosterone catabolism and enhanced intracellular binding contribute to accumulation.
    • Estrogen accelerates the process by increasing androgen receptor levels, enabling growth despite declining androgen production.

    Conclusions:

    • A model for prostatic hyperplasia pathogenesis involving dihydrotestosterone, estrogen, and androgen receptors is proposed.
    • Potential medical treatments that do not require chemical castration may be feasible.

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