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Changes in cervical function at parturition.

R J Fitzpatrick

    Annales De Recherches Veterinaires. Annals of Veterinary Research
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Cervical changes during parturition in sheep and goats involve collagen fiber separation and altered mechanical properties. These changes, crucial for cervical dilation, coincide with hormonal shifts and precede prostaglandin surges.

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    Area of Science:

    • Reproductive Biology
    • Veterinary Medicine
    • Biomechanical Engineering

    Background:

    • Parturition involves significant physiological changes in the uterine cervix.
    • Understanding cervical remodeling is key to managing reproductive events in livestock.

    Purpose of the Study:

    • To investigate cervical wall changes in sheep and goats during parturition.
    • To correlate these structural and mechanical alterations with endocrine events.

    Main Methods:

    • Quantitative mechanical testing of isolated cervical tissues (radial loading, tensometry).
    • In vivo assessment of cervical compliance using intracervical balloons.
    • Hormonal analysis (progesterone, estrogen, prostaglandin F).
    • Pharmacological manipulation (dexamethasone, cloprostenol, meclofenamic acid).

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    Main Results:

    • Cervical collagen fibrils showed evidence of separation, linked to glycosaminoglycan interactions.
    • Mechanical tests revealed the cervical wall behaves as two distinct tissues at parturition, with profound changes in the collagen layer.
    • In vivo cervical compliance increased progressively during induced parturition, correlating with progesterone decline and estrogen rise, preceding prostaglandin F surge.
    • Inhibition of prostaglandin synthesis delayed parturition but not cervical compliance increase.

    Conclusions:

    • Cervical remodeling during parturition is a complex process involving collagen changes and altered biomechanical properties.
    • Hormonal shifts, particularly estrogen and progesterone, play a critical role in initiating cervical ripening.
    • Prostaglandins appear to be involved in the timing of parturition but not the initial cervical compliance changes.