Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dysfunction of natural killer cells in multiple sclerosis: a possible pathogenetic factor.

M Benczur, G G Petrányl, G Pálffy

    Clinical and Experimental Immunology
    |March 1, 1980
    PubMed
    Summary

    Natural killer (NK) cell activity is significantly reduced in multiple sclerosis (MS) patients, particularly males with definitive disease. Impaired NK cell response to interferon suggests a potential role in MS pathogenesis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Detection of Activation Antigens on Chronic Lymphocytic Leukaemia Cells.

    Leukemia & lymphoma·2016
    Same author

    50th anniversary of the Hungarian Society for Microbiology (H.S.M.) (a short history).

    Acta microbiologica et immunologica Hungarica·2002
    Same author

    [Effect of the number of transferred embryos on multiple pregnancy].

    Ceska gynekologie·2000
    Same author

    [Embryo transfer after 5 days of culture].

    Ceska gynekologie·2000
    Same author

    [The ovarian hyperstimulation syndrome with pericardial and pleural effusions complicated by supraventricular arrhythmia].

    Casopis lekaru ceskych·2000
    Same author

    Radicality and prognosis of surgical treatment of thoracal carcinoid tumors: a review of 152 operated cases.

    The Thoracic and cardiovascular surgeon·1999

    Area of Science:

    • Immunology
    • Neuroimmunology
    • Cellular Immunology

    Background:

    • Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
    • Natural killer (NK) cells are crucial components of the innate immune system, involved in tumor surveillance and host defense against viruses.
    • Dysregulation of immune responses, including NK cell function, is implicated in the pathogenesis of autoimmune diseases like MS.

    Purpose of the Study:

    • To investigate NK cell activity, antibody-dependent cytotoxicity (ADCC), and interferon responsiveness in patients with multiple sclerosis.
    • To explore the potential link between impaired NK cell function and the aetiopathogenesis of MS.

    Main Methods:

    • NK cell activity was measured against the K-562 tumor cell line.
    • The effect of interferon (IFN) and polyinosinic-polycytidylic acid (poly I:C) on NK cell activity was assessed.

    Related Experiment Videos

  • Interferon production capacity of lymphocytes was preliminarily determined in a subset of patients.

    • Main Results:

    • NK cell activity was significantly lower in MS patients compared to controls, especially in males with definitive MS.
    • NK cells from MS patients showed an impaired response to interferon, with minimal activation observed after poly I:C stimulation.
    • Preliminary data indicated a defect in the interferon-producing capacity of lymphocytes in definitive MS cases.

    Conclusions:

    • MS patients exhibit significantly reduced NK cell activity and impaired responsiveness to interferon.
    • These findings suggest a potential role for defective NK cell function in the development and progression of multiple sclerosis.
    • Further research is warranted to elucidate the precise mechanisms and therapeutic implications of NK cell dysfunction in MS.