Related Experiment Video
Updated: Aug 11, 2026

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies
Published on: February 23, 2018
Cell-mediated immune response of human lymphocytes to influenza A/USSR (H1N1) virus infection
Abstract:
Cell-mediated immunity to influenza A/USSR (H1N1) virus was assessed by measuring transformation response and interferon production by Ficoll-Hypaque-purified peripheral blood lymphocytes from children and adults. Lymphocyte transformation was found to be related to the individual's previous experience with H1N1 influenza virus. Lymphocyte cultures, obtained from adults who had their last contact with the H1N1 virus over 20 years ago, were able to transform when incubated with H1N1 influenza antigens. This response suggests that influenza virus can induced long-term cell-mediated immunity for periods of at least 20 years. Interferon produced by stimulated lymphocytes was found to be unrelated to previous contact with influenza H1N1 virus; seronegative as well as seropositive individuals were capable of producing interferon in response to viral antigens. The interferon produced was type I.
More Related Videos
12:09Measuring Influenza Neutralizing Antibody Responses to A(H3N2) Viruses in Human Sera by Microneutralization Assays Using MDCK-SIAT1 Cells
Published on: November 22, 2017
07:07Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
Published on: June 27, 2020
Related Concept Videos
Cell-mediated Immune Responses
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Cytomegalovirus Disease
Influenza