[Quantitative changes of rat's alpha 2 macroglobulin concentration by influence of carbon tetrachloride (author's...

We examined the influence of carbon tetrachloride on the rat liver by means of some biological parameters (body mass, GPT-activity, time of hexobarbital narcosis, aminophenazone demethylation) in comparison to the relative concentration of alpha 2 AP under conditions of a long time experiment (8 weeks). The results show, that merely the alpha 2 AP is altered significant in test groups after 1 d of treatment in comparison to the other parameters. Afterwards, under lasting carbon tetrachloride influence the macroglobulin decreases below normal levels. The potential diagnostic value of the alpha 2 AP for toxicological examinations is discussed.