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Prostacyclin inhibits pancreatic secretion
The American Journal of Physiology
|June 1, 1980
Summary
Prostacyclin (PGI2) slightly stimulates pancreatic secretion alone but potently inhibits it when stimulated by food or hormones. This suggests PGI2 plays a role in regulating pancreatic function, potentially via blood flow effects.
Area of Science:
- Gastroenterology
- Physiology
- Endocrinology
Background:
- Prostacyclin (PGI2) is a key arachidonate metabolite in the GI tract.
- PGI2 influences gastric blood flow and secretion.
- The effect of PGI2 on pancreatic secretion remains largely unknown.
Purpose of the Study:
- To investigate the influence of PGI2 on pancreatic secretion.
- To assess PGI2's effects under basal and stimulated conditions.
- To elucidate the interaction between PGI2 and secretin on pancreatic bicarbonate secretion.
Main Methods:
- Intravenous administration of graded doses of PGI2 in fasted dogs.
- Stimulation of pancreatic secretion using a liver meal, duodenal acid/amino acid perfusion, and intravenous secretin/caerulein.
- Kinetic analysis of PGI2 and secretin interaction on bicarbonate secretion.
Main Results:
- PGI2 alone induced minimal pancreatic bicarbonate and protein secretion.
- PGI2 significantly inhibited pancreatic secretion stimulated by various factors.
- Kinetic analysis revealed a mixed-type interaction between PGI2 and secretin, reducing secretory capacity and sensitivity.
- PGI2 caused a notable decrease in arterial blood pressure.
Conclusions:
- Prostacyclin (PGI2) exerts a potent inhibitory effect on pancreatic secretion, particularly when stimulated.
- PGI2's inhibition may be partly mediated by reduced pancreatic blood flow due to its hypotensive effect.
- PGI2 modulates pancreatic secretion, impacting both its capacity and responsiveness to secretin.