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A normal paediatric amylase range.

P J Aggett, F Taylor

Archives of Disease in Childhood

|March 1, 1980

Summary

This summary is machine-generated.

This study established normal plasma alpha-amylase ranges for children, finding activity increases in infancy and reaching mature levels by nine months. These findings are crucial for pediatric diagnostics.

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Area of Science:

Biochemistry
Pediatrics
Clinical Diagnostics

Background:

Plasma alpha-amylase is a key enzyme in carbohydrate metabolism.
Establishing age-specific reference ranges is vital for accurate pediatric diagnosis.
Previous data on infant plasma alpha-amylase activity is limited.

Purpose of the Study:

To determine the normal pediatric range of plasma alpha-amylase activity.
To characterize the developmental changes in plasma alpha-amylase during infancy.

Main Methods:

Utilized the Phadebas blue starch method for plasma alpha-amylase assay.
Collected plasma samples from a cohort of pediatric subjects across different age groups.

Main Results:

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Established a normal range of 98-405 IU/l for children over one year of age.
Observed a significant increase in plasma amylase activity throughout infancy.
Noted that mature amylase activity levels were achieved in most children by nine months of age.

Conclusions:

Defined normative plasma alpha-amylase values for pediatric populations.
Highlighted the dynamic changes in amylase activity during early childhood development.
Provided essential reference data for the clinical interpretation of amylase levels in infants and children.