[Effect of lipid normalizers (clofibrate and procetofene) on chylomicron metabolism in rats]

Clofibrate (250 mg/kg/day) and Procetofene (100 mg/kg/day) feedings determine a significant increase of the rat liver weight. After intravenous injection in treated and control rats of doubly labelled chylomicrons ([14C] glycerol and [3H] oleic acid) an enhancement of radioactive triglyceride hydrolysis was observed in the treated groups. The oxidation of exogenous oleic acid was increased by both drug feeding. Alterations of liver and blood lipids (especially large amounts of labelled diglycerides in the blood) could be probably related to the inhibition of the diglyceride acyltransferase in the liver.