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Creatinine: a review.

S Narayanan, H D Appleton

    Clinical Chemistry
    |July 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    This review covers urinary creatinine measurement for assessing 24-hour urine collection completeness and clinical utility. It examines the Jaffé reaction, its limitations, and alternative creatinine measurement techniques.

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    Area of Science:

    • Clinical Chemistry
    • Biochemical Analysis

    Background:

    • Creatinine measurement is crucial for various clinical applications.
    • Accurate assessment of 24-hour urine collection is vital for reliable diagnostic interpretation.
    • Creatinine clearance ratios are important for evaluating kidney function and analyte clearance.

    Purpose of the Study:

    • To review the use of urinary creatinine as an index of 24-hour urine collection completeness.
    • To discuss the clinical utility of creatinine clearance ratios.
    • To assess different methods for creatinine measurement, including the Jaffé reaction and alternatives.

    Main Methods:

    • Literature review of studies on urinary creatinine determination.
    • Analysis of the chemistry and variables affecting the Jaffé reaction.

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  • Evaluation of alternative creatinine assay techniques.

    • Main Results:

    • Urinary creatinine determination is a valid index for 24-hour urine collection completeness.
    • Creatinine clearance ratios have significant clinical utility.
    • The Jaffé reaction has limitations in specificity, prompting the development of alternative methods.

    Conclusions:

    • Accurate creatinine measurement is essential for clinical diagnostics.
    • Understanding the Jaffé reaction's limitations is key to selecting appropriate assays.
    • Alternative creatinine measurement techniques offer improved specificity and reliability.