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Maturation of B-cell clones

J J Fung, K Gleason, R Ward

    Progress in Clinical and Biological Research
    |January 1, 1980
    PubMed

    The maturation of B-cells was investigated in adoptive transfers and splenic foci. Anti-idiotypic antigens were used to identify clones responding to PC and dextran. A distinct temporal hierarchy of responsiveness could be observed in which the anti-TNP response appears first, followed by anti-dextran and anti-PC. Tolerance induction and anti-idiotype suppression were used as markers for maturing B-cells responding in splenic foci. A differential susceptibility to these manipulations establishes two types of progenitor cells. A scheme for the maturational steps of B-cells is proposed.

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