Effect of lindane on antibody response to typhoid vaccine in weanling rats

The immunosuppressive effect of lindane was assessed in weanling rats over a period of 5 weeks. Agglutinin titres against S. typhi 'O' and 'H', S. paratyphi 'AH' and 'BR' antigens were determined following TAB vaccination in control and lindane-fed animals. The titres attained in non-treated controls were higher significantly than those in treated animals indicating a suppressive effect of lindane on humoral immune responses.