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A monoclonal antibody for large-scale purification of human leukocyte interferon

D S Secher, D C Burke

    Nature
    |June 12, 1980
    PubMed

    A clone of hybrid myelomas (NK2), secreting a mouse monoclonal antibody to human leukocyte interferon, has been isolated. The antibody neutralizes the antiviral activity of the interferon and, when covalently attached to a solid support and used as an immunoadsorbent, allows interferon purification of up to 5,000-fold in a single step.

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