Follow-up study of presumed ocular histoplasmosis syndrome

One hundred and sixty-two patients with presumed ocular histoplasmosis syndrome were evaluated. New macular scars not present on initial angiogram developed in 9% of eyes. The risk of developing a symptomatic macular lesion in eyes with asymptomatic macular scars was 23%. In eyes with peripapillary scarring, 3.8% developed a peripapillary neovascular membrane. Follow-up was 5.5 years. When the neovascular membrane was touching or outside the foveal avascular zone, the difference between photocoagulated and control eyes was not statistically significant. When only adequately photocoagulated eyes (20) were compared with control eyes (40), the difference was statistically significant (P = 0.04).