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Pattern shift visual evoked potentials in Charcot-Marie-Tooth disease, HMSN type I
Journal of Neurology
|January 1, 1980
Summary
Pattern shift visual evoked potentials reveal optic nerve involvement in Charcot-Marie-Tooth disease (HMSN I). This suggests subclinical neuropathy may be more common than previously thought.
Area of Science:
- Neuroscience
- Ophthalmology
- Genetics
Background:
- Charcot-Marie-Tooth disease (HMSN I) is a hereditary neuropathy.
- Clinical examinations may not detect all affected nerve pathways.
Purpose of the Study:
- To investigate optic nerve function in patients with HMSN I using visual evoked potentials.
- To determine the frequency of optic nerve involvement in HMSN I.
Main Methods:
- Pattern shift visual evoked potentials (VEPs) were recorded in 9 subjects diagnosed with HMSN I.
- Subjects were classified based on clinical, genetic, and electromyographic criteria.
Main Results:
- Increased latency of the second positive peak in VEPs was observed in 7 eyes across 5 subjects.
- This indicates a delay in visual signal processing.
Conclusions:
- Optic nerve dysfunction is more common in HMSN I than clinically apparent.
- VEPs are a valuable tool for detecting subclinical optic nerve involvement in Charcot-Marie-Tooth disease.