Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[3H]Digoxin in the optic tract in digoxin intoxication.

P F Binnion, G Frazer

    Journal of Cardiovascular Pharmacology
    |September 1, 1980
    PubMed
    Summary

    Digoxin, a heart medication, concentrates most in the eye's choroid-retina, explaining visual disturbances during digitalis intoxication. Post-mortem, digoxin levels increase in vitreous humor due to retinal release.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Idiopathic Hyperbilirubinaemia.

    Canadian Medical Association journal·2010
    Same author

    The effects of parturition and peripartum complications on the peritoneal fluid composition of mares.

    Theriogenology·2006
    Same author

    Views on AuD.

    ASHA·1992
    Same author

    Identification of cyclophilin as the erythrocyte ciclosporin-binding protein.

    Biochimica et biophysica acta·1988
    Same author

    Severe cerebral ischemia treatment by ventriculosubarachnoid perfusion with an oxygenated fluorocarbon emulsion.

    Neurosurgery·1983
    Same author

    3H-digoxin distribution in the nervous system in ventricular tachycardia.

    Journal of cardiovascular pharmacology·1981

    Area of Science:

    • Pharmacology
    • Ophthalmology
    • Toxicology

    Background:

    • Digitalis intoxication can cause visual disturbances.
    • The precise ocular distribution and binding of digoxin are not fully understood.
    • Hypokalemia may alter drug distribution in the body.

    Purpose of the Study:

    • To determine the tissue distribution of digoxin in the eye, specifically in relation to visual disturbances.
    • To investigate the influence of chronic hypokalemia on digoxin concentration in ocular tissues.
    • To examine post-mortem changes in digoxin distribution within the eye.

    Main Methods:

    • Infusion of [3H]digoxin in normal and hypokalemic dogs until ventricular tachycardia.
    • Measurement of digoxin concentration in ocular tissues, including the choroid-retina and optic tract.
    • Post-mortem analysis of digoxin distribution in an eye left in situ for 3 days.

    Main Results:

    • The highest concentration of digoxin was found in the choroid-retina.
    • Chronic hypokalemia did not significantly affect digoxin concentration or distribution in the optic tract.
    • Post-mortem, digoxin levels increased in the vitreous humor due to release from the choroid-retina.

    Conclusions:

    • The choroid-retina is the primary site for digoxin accumulation, likely responsible for visual changes in digitalis intoxication.
    • The blood-retina barrier may be compromised where the optic nerve passes through the retina, leading to increased digoxin in the optic nerve.
    • Post-mortem release of retinal-bound drugs into the vitreous humor must be considered in forensic pathology.

    Related Experiment Videos