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A tridimensional view of keratoacanthomas.

S G Carrington, W H Wilborn

    Scanning Electron Microscopy
    |January 1, 1980
    PubMed
    Summary

    Human keratoacanthomas, benign skin tumors, originate from hair follicles. Combined microscopy revealed altered keratinocytes and keratin plug formation, offering new insights into tumor anatomy.

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    Area of Science:

    • Dermatology
    • Pathology
    • Microscopy

    Background:

    • Human keratoacanthomas are benign, hyperkeratotic skin tumors.
    • Previous studies have not utilized combined scanning electron microscopy (SEM) and transmission electron microscopy (TEM).

    Purpose of the Study:

    • To investigate the tridimensional anatomy and keratin plug origin in human keratoacanthomas.
    • To correlate findings from SEM and TEM in studying these skin tumors.

    Main Methods:

    • Combined use of scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
    • Analysis of tumor cell morphology, keratinization process, and keratin plug formation.

    Main Results:

    • Tumor cells are modified keratinocytes with altered keratinization, featuring vacuoles and intracellular desmosomes.
    • Keratin plugs originate from hair follicles and extrafollicular tumor cells, surrounded by concentric tumor cell lamellae.
    • Keratinized cells exhibit a "honeycomb" appearance due to interdigitated microridges and microgrooves.

    Conclusions:

    • The study supports the hypothesis that human keratoacanthomas arise from hair follicles.
    • SEM and TEM provide detailed insights into the tridimensional anatomy and pathogenesis of keratoacanthomas.
    • No involvement of sweat ducts, sebaceous glands, or Langerhans cells was observed in the pathogenesis.

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