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Transfer factor from BCG-sensitized mice.

K Sasaki, F Suzuki, N Ishida

    The Tohoku Journal of Experimental Medicine
    |July 1, 1980
    PubMed
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    Transfer factor (TF) research in mice shows it transfers specific immunity. TF activity is dose-dependent, heat-stable, and targets T cells, with thymus involvement crucial for its effects.

    Area of Science:

    • Immunology
    • Cellular Immunology
    • Molecular Immunology

    Background:

    • Transfer factor (TF) is a molecule known to transfer cell-mediated immunity.
    • Understanding the precise mechanisms and properties of TF is crucial for its therapeutic applications.

    Purpose of the Study:

    • To establish a mouse model for studying transfer factor (TF).
    • To characterize the properties and biological activity of mouse TF.
    • To investigate the role of the thymus and T cells in TF-mediated immune responses.

    Main Methods:

    • Extraction of TF from spleens of sensitized mice.
    • Assessment of TF activity using the mouse footpad test.
    • Administration of TF to unsensitized and nude mice, with and without spleen cells.

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    Main Results:

    • Mouse TF exhibited properties similar to human TF.
    • Parenteral TF administration induced specific delayed type hypersensitivity in recipient mice.
    • TF activity was dose-dependent, heat-stable, associated with a low molecular weight fraction, and contained nucleic acids.
    • Nude mice did not respond to TF unless viable spleen cells were administered, indicating thymus and T cell dependence.

    Conclusions:

    • The mouse model effectively replicates TF activity.
    • TF plays a critical role in transferring specific immunity, primarily acting on T cells.
    • The thymus is essential for the expression of TF-induced immune responses.