Biological damage in spleen by iodine-125 in potassium perchlorate blocked thyroid of rats

Studies on spleen have been performed following administration of iodine-125 in perchlorate-treated rats. Although DNA levels did not change appreciably, there was a significant decrease in total RNA following incorporation of iodine-125. Associated with the changes in RNA, there was a significant rise in acid phosphatase and total as well as Mg-dependent ATPases. Increased activity of acid phosphatase seems to be related to the loss of lymphocytes, whereas the rise in ATPase appeared to be associated with cells of red pulp of spleen. It is suggested that damage to the spleen after administration of iodine-125 is due to the Auger effect.