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Updated: Aug 12, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
Published on: May 7, 2010
[Quantitative assessment of human chromosomal polymorphism with regard to paracentromeric heterochromatin]
Abstract:
The measurement of C-segment length in chromosomes 1, 9 and 16 of 7 individuals was carried out. The regression analysis was employed to study a change of the C-segment sizes in the process of mitotic chromosome condensation. Typical values of C-segment length for chromosomes 1, 9 and 16 are about 1.4, 1.1 and 0.8mu respectively. Among 7 individuals there was no two which had identical size of C-segments for all three chromosomes studied. In six individuals heteromorphysm of C-segments was revealed. It was found that visually detected heteromorphysm may be expressed quantitatively as ratio length of C-segments in homologous chromosomes.
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