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Evidence for autapses in the substantia nigra.

A B Karabelas, D P Purpura

    Brain Research
    |November 3, 1980
    PubMed
    Summary

    Researchers identified autaptic neurons in the cat substantia nigra pars reticulata. These neurons send recurrent collaterals that synapse back onto their own dendrites, forming a unique feedback loop.

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    Area of Science:

    • Neuroscience
    • Cell Biology

    Background:

    • The substantia nigra pars reticulata (SNpr) is a key component of the basal ganglia.
    • Understanding neuronal connectivity within the SNpr is crucial for deciphering its function.

    Purpose of the Study:

    • To investigate the recurrent connectivity of cat substantia nigra pars reticulata neurons.
    • To identify and characterize autaptic connections within this neuronal population.

    Main Methods:

    • Intracellular recording techniques were used to monitor neuronal activity.
    • Intracellular horseradish peroxidase (HRP) staining was employed for neuronal tracing and morphological analysis.

    Main Results:

    • Autaptic neurons within the SNpr were successfully labeled.
    • The axon of an autaptic neuron was observed to form recurrent collaterals that contacted the dendrites of the parent neuron.
    • Antidromic stimulation of the ventromedial thalamus induced a recurrent inhibitory postsynaptic potential (IPSP) in the autaptic neuron.

    Conclusions:

    • Cat substantia nigra pars reticulata neurons exhibit autaptic self-connections.
    • These autaptic connections involve recurrent collaterals synapsing onto the parent neuron's dendrites.
    • Autaptic feedback may play a role in regulating SNpr neuronal activity.

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