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Updated: Jul 1, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Acute pancreatitis. Experimental evaluation of steroid, albumin and trasylol therapy
Abstract:
The efficacy of steroids, albumin and Trasylol administration in the treatment of experimental pancreatitis was evaluated. An isolated, ex vivo, perfused canine pancreas preparation was used and pancreatitis was initiated by free fatty acid infusion. Steroid administration worsened pancreatitis, Trasylol had no effect, and albumin was markedly effective in ameliorating pancreatitis. These results were interpreted as evidence against enzyme extravasation and for capillary injury as the initial step in the pathogenesis of pancreatitis.
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Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Clinical Manifestations and Management
Chronic Pancreatitis II: Collaborative Care
Assessment:
Acute Pancreatitis I: Introduction
Acute Pancreatitis II: Pathophysiology