Granulopoietic activity (GA) and colony stimulating factor (CSF) in myeloproliferative diseases

Granulopoietic activity (GA) in vivo and colony stimulating factor (CSF) in vitro were measured in sera of patients with acute and chronic myeloid leukaemia, chronic lymphatic leukaemia and Hodgkin's disease. Before testing sera were dialysed for removing unspecific lipoproteid inhibitors of CSF. We have found a lower activity of CSF in these diseases than in the control group. GA was even below zero stimulation especially in chronic leukaemias. This confirms the presence of inhibitory effect of the tested sera on granulopoiesis in vivo and indicated that GA tested in vivo may be more favourable for the prognosis of leukaemias.