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Endogenous psychoses and T and B lymphocytes.

M Dvoráková, P Zvolský, P Herzog

    Folia Haematologica (Leipzig, Germany : 1928)
    |January 1, 1980
    PubMed
    Summary

    Psychotic patients showed altered active T lymphocytes and B lymphocytes. Lithium and phenothiazine neuroleptics significantly increased active T cells, impacting B lymphocyte levels in depression and schizophrenia treatment.

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    Area of Science:

    • Immunology
    • Psychiatry

    Background:

    • Psychotic disorders like depression and schizophrenia are associated with immune system dysregulation.
    • Lymphocyte subsets, including T and B cells, play crucial roles in immune responses and mental health.

    Purpose of the Study:

    • To investigate changes in active T lymphocytes and B lymphocytes in psychotic patients.
    • To assess the impact of psychotropic medications, specifically lithium and phenothiazine neuroleptics, on these lymphocyte populations.

    Main Methods:

    • Utilized the rosette test to quantify active T lymphocytes (aE rosettes) and B lymphocytes (EA and EAC rosettes).
    • Analyzed lymphocyte subsets in 42 patients diagnosed with psychotic disorders, including depression and schizophrenia.
    • Compared lymphocyte levels between patient groups and a general population sample.

    Main Results:

    • Psychotic patients exhibited an increase in active T lymphocytes and a decrease in B lymphocytes compared to controls.
    • Active T lymphocytes were more prevalent in depressed patients, while both T and B lymphocytes were less frequent in schizophrenic patients.
    • Treatment with lithium and phenothiazine neuroleptics significantly increased active T lymphocytes (P < .05), with a pronounced effect when used concurrently.
    • Concurrent use of lithium and phenothiazines led to a significant increase in active T cells and a significant decrease in B lymphocytes (P < .001).

    Conclusions:

    • Lymphocyte subset alterations are evident in psychotic patients, varying between depression and schizophrenia.
    • Lithium and phenothiazine neuroleptics demonstrably influence T and B lymphocyte levels, suggesting a potential immunomodulatory role in treating these disorders.
    • These findings highlight the interplay between psychiatric conditions, immune function, and psychotropic medication effects.

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