Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroxine-binding proteins.

J Robbins

    Progress in Clinical and Biological Research
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Thyroid hormones interact with plasma proteins like thyroxine-binding globulin (TBG) and transthyretin (TTR). Understanding these interactions is crucial for thyroid function tests and hormone action mechanisms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Author Correction: Universal DNA methylation age across mammalian tissues.

    Nature aging·2023
    Same author

    Universal DNA methylation age across mammalian tissues.

    Nature aging·2023
    Same author

    Oxygennesis for the Instantaneous Production of Pure Oxygen without Heat.

    Chicago medical examiner·2023
    Same author

    Provision of High Protein Foods Slows the Age-Related Decline in Nutritional Status in Aged Care Residents: A Cluster-Randomised Controlled Trial.

    The journal of nutrition, health & aging·2023
    Same author

    Effect of dietary sources of calcium and protein on hip fractures and falls in older adults in residential care: cluster randomised controlled trial.

    BMJ (Clinical research ed.)·2021
    Same author

    Diagnosis of gestational diabetes during the pandemic: what is the risk of falling through the net?

    Diabetic medicine : a journal of the British Diabetic Association·2020
    Same journal

    DNA homology and chromosome stability: a sensitive yeast genetic system for identifying double-stranded DNA damage.

    Progress in clinical and biological research·2018
    Same journal

    Endotoxin and sepsis: molecular mechanisms of pathogenesis, host resistance, and therapy. Proceedings of the 4th Conference of the International Endotoxin Society. Nagoya, Japan, October 23-27, 1996.

    Progress in clinical and biological research·1998
    Same journal

    The pathogenic role of LBP in gram-negative sepsis and septic shock.

    Progress in clinical and biological research·1998
    Same journal

    The role of interleukin 6 in endotoxin-induced inflammatory responses.

    Progress in clinical and biological research·1998
    Same journal

    Role of nitric oxide and reactive oxygen species in endotoxin shock.

    Progress in clinical and biological research·1998
    Same journal

    Interaction of lipopolysaccharide with a mammalian lyso-phosphatidate acyltransferase (LPAAT) transfected into E. coli, and effect of lisofylline on LPAAT transfected into mammalian cells.

    Progress in clinical and biological research·1998
    See all related articles

    Area of Science:

    • Biochemistry
    • Endocrinology
    • Molecular Biology

    Background:

    • Thyroid hormones are small molecules that interact with proteins in the body.
    • These interactions are particularly important in the plasma, involving proteins like thyroxine-binding globulin (TBG) and transthyretin (TTR).

    Purpose of the Study:

    • To discuss hormone-protein interactions in plasma, focusing on TBG and TTR.
    • To highlight the importance of understanding these interactions for diagnostic tests and elucidating hormone action mechanisms.

    Main Methods:

    • The study focuses on the existing knowledge of thyroid hormone-protein interactions in plasma.
    • It emphasizes the significance of protein isolation and characterization, specifically TBG and TTR.

    Main Results:

    Related Experiment Videos

    • TBG exhibits extremely high interaction energy with thyroid hormones, suggesting a specialized binding role.
    • TTR plays a peculiar role in transporting both vitamins and thyroid hormones, though its specific function remains unclear.
    • Variations in these proteins are critical for interpreting thyroid function diagnostic tests.

    Conclusions:

    • Thyroid hormone-protein interactions, particularly with TBG and TTR, serve as vital models for studying hormone binding.
    • Advances in characterizing TBG and TTR offer insights into different binding site chemistries.
    • This knowledge is expected to advance our understanding of hormone action at the cellular level.