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Related Experiment Videos

Tolerance as an active process.

J M Teale, N R Klinman

    Nature
    |November 27, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Neonatal B lymphocytes require protein synthesis for tolerance induction, triggered by antigen binding to cell receptors. This process is initiated only after a minimum threshold affinity and receptor interlinkage.

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    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • The clonal deletion model explains self-tolerance, proposing antigen contact during lymphocyte maturation leads to specific cell inactivation.
    • Immature B lymphocytes exhibit heightened sensitivity to tolerance induction compared to adult cells, even with immunogenic antigens.

    Purpose of the Study:

    • To investigate the mechanism of tolerance in immature B cells.
    • To determine if tolerance is an active process and identify specific inducing interactions.

    Main Methods:

    • Utilized the splenic focus assay to assess tolerance susceptibility in individual B cells.
    • Employed various putative inhibitors to study tolerance induction mechanisms.

    Main Results:

    • Tolerance induction in immature B cells necessitates protein synthesis.

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  • A minimum threshold affinity of antigen binding to cell-surface receptors, followed by receptor interlinkage, is required to initiate tolerance.

    • Conclusions:

    • Neonatal B cell tolerance is an active, protein synthesis-dependent process.
    • Specific antigen-receptor binding affinity and subsequent interlinkage are critical for initiating B cell tolerance.