Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Neuropeptides in regulation].

K Hecht, P Oehme, M Airapetjanz

    Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
    |May 15, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Thyrotropin-releasing hormone acts as both a releaser and neuroregulator, influencing thyroid function and exhibiting antipsychotic effects. Substance P also demonstrates a universal normalizing function in regulatory processes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Professor Dr. sc. med.Walter Schilling (14th July 1932–7th April 2014)].

    Pneumologie (Stuttgart, Germany)·2014
    Same author

    [Biological rhythms and sleep rhythms].

    Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2008
    Same author

    Noise-induced annoyance and morbidity results from the pan-European LARES study.

    Noise & health·2007
    Same author

    High HSP70-membrane expression on leukemic cells from patients with acute myeloid leukemia is associated with a worse prognosis.

    Leukemia·2006
    Same author

    Expression of poliovirus receptor-related proteins PRR1 and PRR2 in acute myeloid leukemia: first report of surface marker analysis, contribution to diagnosis, prognosis and implications for future therapeutical strategies.

    European journal of haematology·2005
    Same author

    [Noise induced annoyance and morbidity. Results from the pan European LARES-survey].

    Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2005
    Same journal

    [Report on the Fifth International Congress on Blood Transfusion, Paris, 13 to 19 September 1954].

    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete·2014
    Same journal

    [Blood coagulation; literature from 1952 to 1954. VI].

    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete·2014
    Same journal

    [Blood coagulation; publications from 1952-1954. V].

    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete·2014
    Same journal

    [Blood coagulation from 1952-1954. IV].

    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete·2014
    Same journal

    [Report on the fourth congress of the European Gastroenterological Society in Paris, 27 June to 2 July 1954].

    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete·2014
    Same journal

    [The islands of Langerhans in pancreatic carcinoma].

    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete·2014
    See all related articles

    Area of Science:

    • Neuroendocrinology
    • Neuropharmacology

    Context:

    • The hypothalamus regulates the thyroid gland via neural and neurohormonal pathways, integrating limbic system functions.
    • Thyrotropin-releasing hormone (TRH) is a key tripeptide with dual roles in endocrine and neurological regulation.

    Purpose:

    • To elucidate the dual function of thyrotropin-releasing hormone (TRH) as both an endocrine releaser and a neuroregulator.
    • To investigate the potential of peptide analogs, like Substance P, to exhibit similar normalizing regulatory functions.

    Summary:

    • TRH stimulates the pituitary to release thyroid-stimulating hormone, thereby controlling thyroid hormones (T3 and T4) and adapting the body to functional demands.
    • As a neuroregulator, TRH influences arousal, muscle tension, temperature, and the efficacy of neuropharmacological agents, with known antipsychotic and antidepressant properties.

    Related Experiment Videos

  • Studies on Substance P in hypertensive rat models suggest a universal normalizing function, correcting both hyper- and hyporeactive regulatory states.

    • Impact:

    • Demonstrates the multifaceted roles of TRH beyond thyroid regulation, highlighting its impact on mood and neurological conditions.
    • Establishes Substance P and its analogs as potential therapeutic agents for a range of regulatory disorders.
    • Proposes a novel mechanism involving probability and improbability relations to explain the normalizing effects of these peptides.