On acquired hemophilia A. A survey of 11 cases

Acquired hemophilia A due to antibodies of factor VIII procoagulant activity is rare. This paper reports 11 such patients followed up for long periods. The exemplify various forms of associated disorders. Four of them have died from hemorrhages, 4 have had complete remission and 3 are still alive with persistent inhibitors. The inhibitor activity was recovered in the immunoglobulin fraction in all the patients studied. Various forms of treatment were tried but remission related to therapy was seen in only one woman affected post partum. Spontaneous remissions are common and the aim of therapy must be to control acute severe hemorrhage.