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Local immunity in mumps meningitis.

T Morishima, M Miyazu, T Ozaki

    American Journal of Diseases of Children (1960)
    |November 1, 1980
    PubMed
    Summary
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    This study found significant mumps virus antibody synthesis within the central nervous system (CNS) of children with mumps meningitis. Interferon activity was also detected during the acute phase, correlating with disease course.

    Area of Science:

    • Neurology
    • Immunology
    • Virology

    Background:

    • Mumps meningitis is a common cause of viral meningitis in children.
    • Understanding the immune response within the central nervous system (CNS) is crucial for managing this condition.

    Purpose of the Study:

    • To investigate antibody and interferon responses in the cerebrospinal fluid (CSF) and serum of children with mumps meningitis.
    • To determine if antibody synthesis occurs within the CNS during mumps meningitis.

    Main Methods:

    • Collected sera and cerebrospinal fluid (CSF) from 15 children diagnosed with mumps meningitis.
    • Measured antibody titers to mumps and measles viruses.
    • Assessed interferon activity in both CSF and serum samples.
    • Calculated CSF-serum ratios for antibody activity and IgG/IgM antibody ratios.

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    Main Results:

    • Antibodies to mumps virus were detected in 11 out of 15 CSF samples.
    • Significantly higher CSF-serum ratios for mumps virus antibodies, particularly IgG, suggest local antibody synthesis in the CNS.
    • CSF antibody titers peaked 4-10 days post-onset and then declined.
    • Interferon activity was present in most acute cases, with levels higher in serum than CSF.
    • Interferon persisted in CSF in cases with persistent pleocytosis.

    Conclusions:

    • Evidence supports intrathecal (within the CNS) antibody synthesis, predominantly IgG, in mumps meningitis.
    • Interferon plays a role in the acute phase response to mumps meningitis.
    • The duration of interferon presence may correlate with ongoing inflammation in the CNS.